Protein–protein interactions and lens transparency
نویسندگان
چکیده
منابع مشابه
The lens: local transport and global transparency.
The perception of the lens changed remarkably during the career of David Maurice. The early view was that it was an inert sack of protein that assisted the cornea in focusing light on the retina. As investigators looked more carefully, more and more complexity was revealed and today we know the lens is a living, dynamic organ that carries out a host of biochemical and physiological processes ne...
متن کاملMolecular solutions to mammalian lens transparency.
The mammalian lens generates an internal microcirculation that maintains transparency in the avascular lens. Significant progress has been made in characterizing the membrane transport proteins associated with this circulation. By combining physiological and molecular evidence, a more comprehensive understanding of normal lens function and cataractogenesis is emerging.
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Motivation: The promises of the post-genome era disease-related discoveries and advances have yet to be fully realized, with many opportunities for discovery hiding in the millions of biomedical papers published since. Public databases give access to data extracted from the literature by teams of experts, but their coverage is often limited and lags behind recent discoveries. We present a compu...
متن کاملThe function of filensin and phakinin in lens transparency
PURPOSE Beaded filaments are lens cell-specific intermediate filaments composed of two proteins: filensin and phakinin (CP49). Filensin and phakinin are believed to function in the maintenance of lens transparency. To elucidate the function of filensin and phakinin at the molecular level, we examined the degradation of these two proteins in normal and cataractous rat lenses. METHODS A heredit...
متن کاملpCMPS-induced changes in lens membrane permeability and transparency.
PURPOSE To investigate the role of externally facing membrane protein sulfhydryl groups in controlling lens permeability and transparency using the impermeant sulfhydryl complexing agent p-chloromercuriphenyl sulfonate (pCMPS). METHODS Membrane permeability changes were studied by measuring lens voltage and resistance. Ion movements were monitored by measuring 22Na+ and 45Ca2+ fluxes, and int...
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ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2008
ISSN: 0014-4835
DOI: 10.1016/j.exer.2008.08.018